Which risk is associated with estrogen therapy for menopausal women?

Estrogen therapy, commonly prescribed to alleviate menopausal symptoms, is associated with an increased risk for thromboembolic events. This refers to the formation of blood clots that can lead to serious complications such as deep vein thrombosis (DVT), pulmonary embolism, and stroke. The mechanism behind this increased risk involves estrogen's effect on the coagulation system, which can enhance blood clotting.

While estrogen does have various health effects, including a potential positive influence on bone density, cardiovascular health, and breast tissue, the adverse event concerning thromboembolic events remains a significant concern. For menopausal women considering hormone therapy, it is critical to weigh these risks against the benefits in conjunction with their healthcare provider.